Inotropic Action of Hexamethonium

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Inotropic action of hexamethonium.

The positive inotropic action of hexainethoniuin in hypodynamic and freshly prepared papillary muscles of the cat and the hypodynamic heart-lung preparation of the dog has been demonstrated. Within certain limits, there exists a proportionality between the concentration of hexamethonium and the magnitude of the inotropic response. In both preparations results have been obtained which indicate t...

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Nature of the Inotropic Action of Angiotensin on Ventricular Myocardium.

• Angiotensin u has a significant positive inotropic action on mammalian ventricular myocardium. In the intact circulation this action is modified or masked by the vascular effects of angiotensin which lead to coronary vasoconstriction and to marked increases of total peripheral resistance. '~ On the other hand, when myocardial contractility is determined directly and when secondary effects of ...

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Nature of the Inotropic Action of Angiotensin on Ventricular Myocardium

• Angiotensin u has a significant positive inotropic action on mammalian ventricular myocardium. In the intact circulation this action is modified or masked by the vascular effects of angiotensin which lead to coronary vasoconstriction and to marked increases of total peripheral resistance. '~ On the other hand, when myocardial contractility is determined directly and when secondary effects of ...

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Contraction dependency of the positive inotropic action of cardiac glycosides.

The concept that the positive inotropic effect of cardiac glycosides is dependent on the contractile state of the myocardium was tested. Isolated left atria of rabbits, when driven electrically at 15, 30, 60 and 120/min (at 30, 33, or 37°C), responded to ouabain (1 yug/ml) in proportion to the number of contractions and not to the time of exposure or frequency of drive. Contraction-related effe...

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Positive inotropic action of insulin on piglet heart.

This study was designed to investigate changes in cardiac performance during hypoglycemia produced by the administration of insulin in the newborn piglet. With heart rate, aortic pressure, and aortic flow held constant, the treated group demonstrated a pronounced positive inotropic response manifested by an increase of dP/dt max to 138% of control values. Central nervous system function and bet...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 1958

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.6.1.66